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KMID : 0380620180500050543
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Korean Journal of Food Science and Technology
2018 Volume.50 No. 5 p.543 ~ p.548
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Antioxidant and neuroprotective effects of crude polysaccharide fractions from Cudrania tricuspidata fruits
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Kim Yi-Eun
Cho Eun-Ji
Byun Eui-Hong
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Abstract
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The current study examined antioxidant and neuronal cell protective effects of the crude polysaccharide fraction in Cudrania tricuspidata fruits (CTP). The radical scavenging activities of (1,1-diphenyl-picrylhydrazyl and 2,2'-azino-bis- (3-ethylbenzothiazoline-6-sulfonic acid)) and reducing power and FRAP of CTP were increased dose-dependently. In addition, the expression of neuroprotective effect of CTP was tested in HT22 mouse hippocampal cells. CTP treatment exhibited non cytotoxicity at dose levels below 500 μg/mL. Within this optimal concentration range, CTP treatment significantly increased cell viability in H2O2-treated HT22 cells. Furthermore, CTP treatment increased superoxide dismutase (SOD) activity and decreased malonaldehyde (MDA) levels in HT22 cells. Therefore, these results indicate that the crude polysaccharide fraction from Cudrania tricuspidata fruits (CTP) possesses antioxidant activities and displays therapeutic potential as a useful source material in the development of brain disorder treatments targeting oxidative stress in neuronal cells.
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KEYWORD
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Cudrania tricuspidata fruits, polysaccharide, neuroprotective effects, antioxidant, neuronal cell
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